Somatostatin Reduces the Acute Lung Injury of Mice via Increasing the Affinity of Glucocorticoid Receptor
Author(s) -
Yan Zhao,
Min Zhang,
RenPing Xiong,
Xingyun Chen,
Ping Li,
YaLei Ning,
Nan Yang,
Yan Peng,
YuanGuo Zhou
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000443079
Subject(s) - glucocorticoid receptor , lung , glucocorticoid , hsp70 , somatostatin , hsp90 , heat shock protein , receptor , medicine , endocrinology , somatostatin receptor , chemistry , pharmacology , biochemistry , gene
Although it has been reported that somatostatin (SOM) upregulated the level of 90-kD heat shock protein (Hsp90), which participates in the inflammatory regulation by its client proteins, such as glucocorticoid receptor (GR), it remains unclear if it has a protective role against acute lung injury (ALI).
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