TheBDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies | Zendy

Shuo Chen | Zendy; Lei Zhang | Zendy; Ruonan Xu | Zendy; Yunfan Ti | Zendy; Yunlong Zhao | Zendy; Liwu Zhou | Zendy; Jianning Zhao | Zendy

Open Access

TheBDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies

Author(s) -

Shuo Chen,

Lei Zhang,

Ruonan Xu,

Yunfan Ti,

Yunlong Zhao,

Liwu Zhou,

Jianning Zhao

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443072

Subject(s) - osteoarthritis , in vitro , cytokine , medicine , immunology , inflammation , biology , pathology , genetics , alternative medicine

The bradykinin B2 receptor (BDKRB2) +9/-9 gene polymorphisms have been shown to be associated with the susceptibility and severity of osteoarthritis (OA); however, the underlying mechanisms are unclear. In this study, we investigated the correlation between the BDKRB2 +9/-9 polymorphisms and pro-inflammatory cytokine levels in OA and the molecular mechanisms involved.

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