Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer | Zendy

Na Yang | Zendy; Tai-Cheng Zhou | Zendy; Xiu-xia Lei | Zendy; Chang Wang | Zendy; Min Yan | Zendy; Zi-Feng Wang | Zendy; Wei Liu | Zendy; Jian Wang | Zendy; Kai-Hua Ming | Zendy; BiCheng Wang | Zendy; Bang-Lao Xu | Zendy; Quentin Liu | Zendy

Open Access

Inhibition of Sonic Hedgehog Signaling Pathway by Thiazole Antibiotic Thiostrepton Attenuates the CD44+/CD24-Stem-Like Population and Sphere-Forming Capacity in Triple-Negative Breast Cancer

Author(s) -

Na Yang,

Tai-Cheng Zhou,

Xiu-xia Lei,

Chang Wang,

Min Yan,

Zi-Feng Wang,

Wei Liu,

Jian Wang,

Kai-Hua Ming,

BiCheng Wang,

Bang-Lao Xu,

Quentin Liu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443066

Subject(s) - thiostrepton , cd44 , cancer research , triple negative breast cancer , population , biology , sonic hedgehog , cancer stem cell , stem cell , microbiology and biotechnology , signal transduction , cancer , cell , breast cancer , medicine , biochemistry , genetics , ribosome , rna , environmental health , gene

Triple-negative breast cancer (TNBC) represents a particular clinical challenge because these cancers do not respond to endocrine therapy or other available targeted agents. The lack of effective agents and obvious targets are major challenges in treating TNBC. In this study we explored the cytostatic effect of thiazole ring containing antibiotic drug thiostrepton on TNBC cell lines and investigated the molecular mechanism.

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