Stimulating Effect of Elvitegravir on Suicidal Erythrocyte Death | Zendy

Rosi Bissinger | Zendy; Abdulla Al Mamun Bhuyan | Zendy; Elena Signoretto | Zendy; Florian Läng | Zendy

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Stimulating Effect of Elvitegravir on Suicidal Erythrocyte Death

Author(s) -

Rosi Bissinger,

Abdulla Al Mamun Bhuyan,

Elena Signoretto,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443061

Subject(s) - phosphatidylserine , elvitegravir , apoptosis , biology , reactive oxygen species , microbiology and biotechnology , ionomycin , pharmacology , biophysics , chemistry , intracellular , biochemistry , immunology , phospholipid , membrane , virus , viral load , antiretroviral therapy

The antiviral drug Elvitegravir is used for the treatment of Human Immunodeficiency Virus (HIV) infections. The present study explored whether the drug is able to trigger eryptosis, the suicidal death of erythrocytes. Eryptosis is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Stimulators of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, ceramide, activated p38 kinase and activated caspases. The present study explored, whether Elvitegravir induces eryptosis and, if so, to shed light on the mechanisms involved.

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