Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P) | Zendy

Elena Signoretto | Zendy; Rosi Bissinger | Zendy; Michela Castagna | Zendy; Florian Läng | Zendy

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Stimulation of Eryptosis by Combretastatin A4 Phosphate Disodium (CA4P)

Author(s) -

Elena Signoretto,

Rosi Bissinger,

Michela Castagna,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443049

Subject(s) - phosphatidylserine , ceramide , apoptosis , chemistry , reactive oxygen species , annexin , glutathione , cytosol , flow cytometry , oxidative stress , cell , microbiology and biotechnology , biochemistry , biology , phospholipid , membrane , enzyme

Combretastatin A4 phosphate disodium (CA4P) is utilized for the treatment of malignancy. The substance has previously been shown to trigger suicidal cell death or apoptosis. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Stimulators of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), ceramide, oxidative stress and ATP depletion. The present study explored, whether CA4P induces eryptosis and, if so, to gain insight into mechanisms involved.

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