Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway | Zendy

Xiaqiu Tian | Zendy; Yue-Jin Yang | Zendy; Qing Li | Zendy; Peisen Huang | Zendy; Xiangdong Li | Zendy; Jin Chen | Zendy; Qi Kang | Zendy; Leipei Jiang | Zendy; Gui-Hao Chen | Zendy

Open Access

Globular Adiponectin Inhibits the Apoptosis of Mesenchymal Stem Cells Induced by Hypoxia and Serum Deprivation via the AdipoR1-Mediated Pathway

Author(s) -

Xiaqiu Tian,

Yue-Jin Yang,

Qing Li,

Peisen Huang,

Xiangdong Li,

Jin Chen,

Qi Kang,

Leipei Jiang,

Gui-Hao Chen

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443044

Subject(s) - apoptosis , mesenchymal stem cell , adiponectin receptor 1 , adiponectin , microbiology and biotechnology , gene knockdown , ampk , cancer research , chemistry , biology , endocrinology , protein kinase a , kinase , biochemistry , insulin , insulin resistance

Poor viability of transplanted mesenchymal stem cells (MSCs) within the ischemic heart limits their therapeutic potential for cardiac repair. Globular adiponectin (gAPN) exerts anti-apoptotic effects on several types of stem cells. Herein, we investigated the effect of gAPN on the MSCs against apoptosis induced by hypoxia and serum deprivation (H/SD).

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