Astrocyte-Derived CCL2 is Associated with M1 Activation and Recruitment of Cultured Microglial Cells | Zendy

Mingfeng He | Zendy; Hongquan Dong | Zendy; Yahui Huang | Zendy; Shunmei Lu | Zendy; Shu Zhang | Zendy; Yanning Qian | Zendy; Wenjie Jin | Zendy

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Astrocyte-Derived CCL2 is Associated with M1 Activation and Recruitment of Cultured Microglial Cells

Author(s) -

Mingfeng He,

Hongquan Dong,

Yahui Huang,

Shunmei Lu,

Shu Zhang,

Yanning Qian,

Wenjie Jin

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443040

Subject(s) - microglia , astrocyte , ccl2 , chemokine , microbiology and biotechnology , tumor necrosis factor alpha , neuroglia , inflammation , ccr2 , neuroinflammation , central nervous system , in vivo , chemistry , biology , immunology , neuroscience , chemokine receptor

Microglia are an essential player in central nervous system inflammation. Recent studies have demonstrated that the astrocytic chemokine, CCL2, is associated with microglial activation in vivo. However, CCL2-induced microglial activation has not yet been studied in vitro. The purpose of the current study was to understand the role of astrocyte-derived CCL2 in microglial activation and to elucidate the underlying mechanism(s).

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