MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1 | Zendy

Lei Yang | Zendy; Dawei Ge | Zendy; Xiaojian Cao | Zendy; Yingbin Ge | Zendy; Hongtao Chen | Zendy; Weiwei Wang | Zendy; Hongxiu Zhang | Zendy

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MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1

Author(s) -

Lei Yang,

Dawei Ge,

Xiaojian Cao,

Yingbin Ge,

Hongtao Chen,

Weiwei Wang,

Hongxiu Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443036

Subject(s) - mesenchymal stem cell , osteoblast , microbiology and biotechnology , alkaline phosphatase , microrna , chemistry , osteoporosis , cancer research , biology , in vitro , endocrinology , biochemistry , gene , enzyme

Postmenopausal osteoporosis is closely associated with reduction in the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. Previous studies have demonstrated that miR-214 plays an important role in the genesis and development of postmenopausal osteoporosis. Here, we performed this study to investigate the potential mechanism by which miR-214 regulates osteoblast differentiation of MSCs.

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