Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling | Zendy

Mona S. Guida | Zendy; Ali Abd El-Aal | Zendy; Yehya Kafafy | Zendy; Safwat Farid Salama | Zendy; Badr Mohamed Badr | Zendy; Gamal Badr | Zendy

Open Access

Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling

Author(s) -

Mona S. Guida,

Ali Abd El-Aal,

Yehya Kafafy,

Safwat Farid Salama,

Badr Mohamed Badr,

Gamal Badr

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000443034

Subject(s) - propidium iodide , apoptosis , cytokine , oxidative stress , thymoquinone , chemistry , endocrinology , flow cytometry , medicine , immunology , biology , programmed cell death , biochemistry , antioxidant

Recent studies have shown that thymoquinone (TQ) exerts protective effects against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats. Nevertheless, there is no published work investigated the effects of TQ on T cell development and biology in animal models exposed to gamma radiation. Therefore, in the present study we focused on determining the effects of TQ on radiation damage in the thymus, radiation-induced T cell imbalance, and on immune dysfunction induced by gamma-rays.

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