SGK3 Sensitivity of Large-Conductance Ca2+-Activated K+ Channel | Zendy

Musaab Ahmed | Zendy; Myriam Fezai | Zendy; Florian Läng | Zendy

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SGK3 Sensitivity of Large-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel

Author(s) -

Musaab Ahmed,

Myriam Fezai,

Florian Läng

Publication year - 2016

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000442618

Subject(s) - bk channel , xenopus , kinase , patch clamp , chemistry , biophysics , phosphorylation , cytosol , microbiology and biotechnology , potassium channel , biology , biochemistry , receptor , enzyme , gene

Large conductance Ca2+-activated K+ channels (maxi K+ channels or BK channels) are rapidly activated by increase of cytosolic Ca2+ activity. The channels participate in the regulation of diverse functions including neuronal excitation and cell volume. The BK channels may be modified by kinases. Channel regulating kinases include the serum & glucocorticoid inducible kinase 3 (SGK3). The present study explored whether SGK3 modifies the activity of BK channels.

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