Wnt / ß-Catenin Signaling Pathway Against Aβ Toxicity in PC12 Cells | Zendy

Yaping Zheng | Zendy; Jin Wang | Zendy; Deheng Li | Zendy; Meixia Guo | Zendy; Zhen Minghui | Zendy; Quanzhong Chang | Zendy

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Wnt / ß-Catenin Signaling Pathway Against Aβ Toxicity in PC12 Cells

Author(s) -

Yaping Zheng,

Jin Wang,

Deheng Li,

Meixia Guo,

Zhen Minghui,

Quanzhong Chang

Publication year - 2016

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000442610

Subject(s) - wnt signaling pathway , viability assay , apoptosis , programmed cell death , microbiology and biotechnology , flow cytometry , signal transduction , blot , wnt3a , catenin , biology , mtt assay , neurotoxicity , tau protein , chemistry , alzheimer's disease , toxicity , biochemistry , medicine , disease , gene , organic chemistry

Alzheimer's disease (AD) is characterized by accumulation of β-amyloid (Aβ), However, the mechanism of how Aβ affects neuronal cell death remains elusive. The balance of pro- and anti-apoptotic Bcl-2 family proteins (e.g., Bcl-2 and Bax) has been known to play a pivotal role in neuronal cell death. Of note, expression levels of these proteins are changed in the neurons in AD. To date no study has elusidated the relationship between Aβ and Bax.

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