Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia | Zendy

Eiji Masaki | Zendy; Kentaro Mizuta | Zendy; Norimasa Ohtani | Zendy; Kanta Kido | Zendy

Open Access

Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia

Author(s) -

Eiji Masaki,

Kentaro Mizuta,

Norimasa Ohtani,

Kanta Kido

Publication year - 2016

Publication title -

neurosignals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.755

H-Index - 67

eISSN - 1424-8638

pISSN - 1424-862X

DOI - 10.1159/000442608

Subject(s) - nociception , microglia , minocycline , medicine , spinal cord , anesthesia , brain derived neurotrophic factor , hyperalgesia , neurotrophic factors , allodynia , neurotrophin , neuroscience , inflammation , receptor , chemistry , psychology , biochemistry , psychiatry , antibiotics

Brain-derived neurotrophic factor (BDNF) from spinal microglia is crucial for aberrant nociceptive signaling in several pathological pain conditions, including postoperative pain. We assess the contribution of spinal microglial activation and associated BDNF overexpression to the early post-incisional nociceptive threshold.

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