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Role of Serum Brain Derived Neurotrophic Factor and Central N-Acetylaspartate for Clinical Response under Antidepressive Pharmacotherapy
Author(s) -
Sarah Nase,
Stephan Köhler,
Jacqueline Jennebach,
Anne Eckert,
Nina Schweinfurth,
Jürgen Gallinat,
Undine E. Lang,
Simone Kühn
Publication year - 2016
Publication title -
neurosignals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.755
H-Index - 67
eISSN - 1424-8638
pISSN - 1424-862X
DOI - 10.1159/000442607
Subject(s) - brain derived neurotrophic factor , antidepressant , medicine , neurotrophic factors , biomarker , depression (economics) , anterior cingulate cortex , major depressive disorder , endocrinology , psychology , psychiatry , receptor , hippocampus , cognition , biochemistry , chemistry , macroeconomics , amygdala , economics
The predictive therapeutic value of brain derived neurotrophic factor (BDNF) and its changes associated with the use of specific antidepressants are still unclear. In this study, we examined BDNF as a peripheral and NAA as a central biomarker over the time course of antidepressant treatment to specify both of their roles in the response to the medication and clinical outcome.

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