Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy | Zendy

Afshin Namdar | Zendy; Hamid Reza Mirzaei | Zendy; Morteza Hafezi | Zendy; Najmeh Khosravianfar | Zendy; Nasim Kheshtchin | Zendy; Reza Mirzaei | Zendy; Jamshid Hadjati | Zendy; Abbas Rezaei | Zendy

Open Access

Low Noncytotoxic Concentrations of 5-Fluorouracil Have No Adverse Effects on Maturation and Function of Bone Marrow-Derived Dendritic Cells in vitro: A Potentially Safe Adjuvant for Dendritic Cell-Based Cancer Therapy

Author(s) -

Afshin Namdar,

Hamid Reza Mirzaei,

Morteza Hafezi,

Najmeh Khosravianfar,

Nasim Kheshtchin,

Reza Mirzaei,

Jamshid Hadjati,

Abbas Rezaei

Publication year - 2015

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000442290

Subject(s) - cd80 , cd86 , bone marrow , immune system , immunology , dendritic cell , cytokine , adjuvant , medicine , cancer research , cd11c , immunotherapy , mhc class ii , t cell , biology , cd40 , in vitro , cytotoxic t cell , phenotype , biochemistry , gene

Low, noncytotoxic concentrations of various chemotherapeutic drugs like 5-fluorouracil (5-FU) induce antitumor immune responses by selectively depleting tumor-induced immunosuppressive cells, and could therefore be used in combination with dendritic cell (DC) vaccines in order to enhance their immunotherapeutic efficacy. However, the likely negative influences of low, noncytotoxic doses of 5-FU on bone marrow-derived (BM)-DCs in vitro have not yet been investigated.

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