The Role of Renal Progenitors in Renal Regeneration | Zendy

Catherine Meyer-Schwesinger | Zendy

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The Role of Renal Progenitors in Renal Regeneration

Author(s) -

Catherine Meyer-Schwesinger

Publication year - 2016

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000442180

Subject(s) - renal stem cell , progenitor cell , medicine , regeneration (biology) , kidney , renal function , compartment (ship) , bone marrow , progenitor , stem cell , pathology , microbiology and biotechnology , biology , oceanography , geology

The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.

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