Food Protein-Induced Non-Immunoglobulin E-Mediated Allergic Colitis in Infants and Older Children: What Cytokines Are Involved? | Zendy

Ahmet Özen | Zendy; E. Mahir Gülcan | Zendy; Hülya Ercan Sarıçoban | Zendy; Ferda Özkan | Zendy; Reha Cengizlier | Zendy

Open Access

Food Protein-Induced Non-Immunoglobulin E-Mediated Allergic Colitis in Infants and Older Children: What Cytokines Are Involved?

Author(s) -

Ahmet Özen,

E. Mahir Gülcan,

Hülya Ercan Sarıçoban,

Ferda Özkan,

Reha Cengizlier

Publication year - 2015

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000441471

Subject(s) - pathogenesis , lamina propria , immunology , medicine , eosinophil , tumor necrosis factor alpha , cd86 , immunohistochemistry , pathology , immune system , t cell , epithelium , asthma

Food protein-induced allergic proctocolitis (FPIAP) is mostly a non-immunoglobulin E-mediated disease where a T-cell-mediated reaction to cow's milk protein has been suggested. We determined the expression of transforming growth factor (TGF)-β, TGF-β receptor-1, tumor necrosis factor (TNF)-α, CD86, and CD23 on the colon mucosa to investigate their roles in the pathogenesis of the two subtypes of FPIAP, i.e. infantile FPIAP and FPIAP in older children.

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