Open AccessRaf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas
Author(s) -
Olga Martinho,
Marcelo Campos,
Guilherme Ribeiro,
Valter Penna,
Emílio Carlos Curcelli,
Marcus V. Olivieri,
Sandra Morini,
Cristovam Scapulatempo,
Lucas Faria Abrahão-Machado,
Rui Manuel Reis
Publication year - 2016
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000441227
Subject(s) - immunohistochemistry , pathological , cancer research , biology , kinase , medicine , pathology , genetics
Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients with STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf kinase inhibitory protein (RKIP) has been associated with prognosis in several human neoplasms; however, its role in STS is unknown.