Open AccessPremature Epiphyseal Closure of the Lower Extremities Contributing to Short Stature after <b><i>cis</i></b>-Retinoic Acid Therapy in Medulloblastoma: A Case Report
Author(s) -
Jessica J. Noyes,
Michael A. Levine,
Jean B. Belasco,
Sogol MostoufiMoab
Publication year - 2015
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000441140
Subject(s) - medicine , short stature , medulloblastoma , endocrinology , bone age , growth hormone deficiency , growth hormone , hormone , pathology
Prolonged cis-retinoic acid (RA) exposure contributes to premature epiphyseal closure. cis-RA is administered in various treatment regimens for pediatric cancers, thus increasing the risk for bone deformities and compromised growth.
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