Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma | Zendy

Atul Batra | Zendy; Seema Kashyap | Zendy; Lata Singh | Zendy; Sameer Bakhshi | Zendy

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Sirtuin1 Expression and Correlation with Histopathological Features in Retinoblastoma

Author(s) -

Atul Batra,

Seema Kashyap,

Lata Singh,

Sameer Bakhshi

Publication year - 2015

Publication title -

ocular oncology and pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.444

H-Index - 10

eISSN - 2296-4681

pISSN - 2296-4657

DOI - 10.1159/000439594

Subject(s) - retinoblastoma , immunohistochemistry , medicine , sirtuin 1 , pathology , retinoblastoma protein , stage (stratigraphy) , cancer research , biology , cancer , gene , downregulation and upregulation , cell cycle , genetics , paleontology

Sirtuin1 (Sirt1) is a member of highly conserved proteins and has been implicated as a tumor promoter as well as a tumor suppressor. One of the mechanisms involves deacetylation of retinoblastoma protein, thereby inhibiting the tumor suppressor function. No study has been reported on the expression of Sirt1 in retinoblastoma.

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