Assessing the Relationship of Angiotensin II Type 1 Receptors with Erythropoietin in a Human Model of Endogenous Angiotensin II Type 1 Receptor Antagonism | Zendy

Lorenzo A. Calò | Zendy; Paul A. Davis | Zendy; Giuseppe Maiolino | Zendy; Elisa Pagnin | Zendy; Verdiana Ravarotto | Zendy; Eleso | Zendy; Gianni Carraro | Zendy; A Naso | Zendy

Open Access

Assessing the Relationship of Angiotensin II Type 1 Receptors with Erythropoietin in a Human Model of Endogenous Angiotensin II Type 1 Receptor Antagonism

Author(s) -

Lorenzo A. Calò,

Paul A. Davis,

Giuseppe Maiolino,

Elisa Pagnin,

Verdiana Ravarotto,

Eleso,

Gianni Carraro,

A Naso

Publication year - 2015

Publication title -

cardiorenal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.661

H-Index - 21

eISSN - 1664-3828

pISSN - 1664-5502

DOI - 10.1159/000439183

Subject(s) - medicine , nox4 , angiotensin ii , erythropoietin , endocrinology , nadph oxidase , receptor , oxidative stress

Angiotensin II (Ang II) has been shown to control erythropoietin (EPO) synthesis as Ang II type 1 receptor (AT1R) blockers block Ang-II-induced EPO oversecretion. To further explore the involvement of AT1R in processes controlling EPO levels, plasma EPO and mononuclear cell NADPH oxidase 4 (NOX4) - a NOX family member involved in oxygen sensing, which is a process central to controlling EPO levels - were assessed in Bartter's/Gitelman's syndrome (BS/GS) patients, a human model of endogenous AT1R antagonism and healthy subjects. Heme oxygenase (HO)-1, antioxidant and anti-inflammatory factor related to NOX4 activation, and the relationship of EPO and NOX4 to HO-1 were also assessed.

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