Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH | Zendy

Barbara Behm | Zendy; Michael Kemper | Zendy; Philipp Babilas | Zendy; Christoph Abels | Zendy; Stephan Schreml | Zendy

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Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

Author(s) -

Barbara Behm,

Michael Kemper,

Philipp Babilas,

Christoph Abels,

Stephan Schreml

Publication year - 2015

Publication title -

skin pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.703

H-Index - 74

eISSN - 1660-5535

pISSN - 1660-5527

DOI - 10.1159/000439030

Subject(s) - glycolic acid , emulsion , stratum corneum , transepidermal water loss , chemistry , human skin , chromatography , dermatology , medicine , biochemistry , biology , pathology , lactic acid , genetics , bacteria

The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.

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