Inflammasomes in the Pathophysiology of Kidney Diseases | Zendy

Humaira Masood | Zendy; Ruochen Che | Zendy; Aihua Zhang | Zendy

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Inflammasomes in the Pathophysiology of Kidney Diseases

Author(s) -

Humaira Masood,

Ruochen Che,

Aihua Zhang

Publication year - 2015

Publication title -

kidney diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9381

pISSN - 2296-9357

DOI - 10.1159/000438843

Subject(s) - inflammasome , pyroptosis , innate immune system , proinflammatory cytokine , immunology , kidney , signal transducing adaptor protein , biology , acute kidney injury , medicine , cancer research , signal transduction , inflammation , microbiology and biotechnology , immune system

The inflammasome is a complex of proteins in the cytoplasm that consists of three main components: a sensor protein (receptor), an adapter protein and caspase-1. Inflammasomes are the critical components of innate immunity and have been gradually recognized as a critical mediator in various autoimmune diseases; also, their role in chronic kidney disease and acute kidney injury has been gradually accepted.

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