Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis | Zendy

Stuart W. Smith | Zendy; Adam P. Croft | Zendy; Hannah L. Morris | Zendy; Amy J. Naylor | Zendy; David L. Huso | Zendy; Clare M. Isacke | Zendy; Caroline O.S. Savage | Zendy; Christopher D. Buckley | Zendy

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Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis

Author(s) -

Stuart W. Smith,

Adam P. Croft,

Hannah L. Morris,

Amy J. Naylor,

David L. Huso,

Clare M. Isacke,

Caroline O.S. Savage,

Christopher D. Buckley

Publication year - 2015

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000438754

Subject(s) - fibrosis , stromal cell , pathology , myofibroblast , medicine , kidney , biology , cancer research

Tissue fibrosis and microvascular rarefaction are hallmarks of progressive renal disease. CD248 is a transmembrane glycoprotein expressed by key effector cells within the stroma of fibrotic kidneys including pericytes, myofibroblasts and stromal fibroblasts. In human disease, increased expression of CD248 by stromal cells predicts progression to end-stage renal failure. We therefore, hypothesized that the genetic deletion of the CD248 gene would protect against fibrosis following kidney injury.

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