Spermine inhibits Endoplasmic Reticulum Stress - induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis | Zendy

Can Wei | Zendy; Yuehong Wang | Zendy; Meixiu Li | Zendy; Hongzhu Li | Zendy; Xiaoxiao Lu | Zendy; Hong-Jiang Shao | Zendy; Changqing Xu | Zendy

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Spermine inhibits Endoplasmic Reticulum Stress - induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis

Author(s) -

Can Wei,

Yuehong Wang,

Meixiu Li,

Hongzhu Li,

Xiaoxiao Lu,

Hong-Jiang Shao,

Changqing Xu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438648

Subject(s) - spermine , apoptosis , endoplasmic reticulum , oxidative stress , reactive oxygen species , spermidine , microbiology and biotechnology , caspase 12 , biology , pharmacology , medicine , chemistry , endocrinology , programmed cell death , caspase , biochemistry , enzyme

Endoplasmic reticulum stress (ERS) plays an important role in the progression of acute myocardial infarction (AMI), in part by mediating apoptosis. Polyamines, including putrescine, spermidine, and spermine, are polycations with anti-oxidative, anti-aging, and cell growth-promoting activities. This study aimed to determine the mechanisms by which spermine protects against ERS-induced apoptosis in rats following AMI.

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