Genomic Alteration During Metastasis of Lung Adenocarcinoma | Zendy

Qiang Tan | Zendy; Jian Cui | Zendy; Jia Huang | Zendy; Zhengping Ding | Zendy; Hao Lin | Zendy; Xiaomin Niu | Zendy; Zhiming Li | Zendy; Guan Wang | Zendy; Qingquan Luo | Zendy; Shun Lu | Zendy

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Genomic Alteration During Metastasis of Lung Adenocarcinoma

Author(s) -

Qiang Tan,

Jian Cui,

Jia Huang,

Zhengping Ding,

Hao Lin,

Xiaomin Niu,

Zhiming Li,

Guan Wang,

Qingquan Luo,

Shun Lu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438644

Subject(s) - metastasis , biology , adenocarcinoma , cancer research , cancer , primary tumor , lung cancer , somatic evolution in cancer , exome sequencing , germline mutation , mutation , tumor progression , epigenetics , gene , pathology , genetics , medicine

Recurrent gene mutation has been identified by the analysis of exonic DNA from lung adenocarcinoma, but its progression has not been extensively profiled. The investigation of the mutational landscape of tumors provides new insights into cancer genome evolution and further discovers the interplay of somatic mutation, adaptation of clones to their environment and natural selection. Cancer development involves cycles of genomic damage, epigenetic deregulation, and increased cellular proliferation that eventually culminate in the carcinoma phenotype.

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