MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration | Zendy

Jin Feng | Zendy; Li Na Zang | Zendy; Yong Ming Xi | Zendy; Wen Jiu Yang | Zendy; Debo Zou | Zendy

Open Access

MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration

Author(s) -

Jin Feng,

Li Na Zang,

Yong Ming Xi,

Wen Jiu Yang,

Debo Zou

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438630

Subject(s) - apoptosis , nucleus , transfection , genotype , intervertebral disc , microrna , allele , biology , pathological , pathology , cell , microbiology and biotechnology , medicine , cell culture , gene , genetics , anatomy

Spinal degenerative diseases are a major health problem and social burden worldwide. Intervertebral disc degeneration (IDD) is the pathological basis of spinal degenerative diseases and is characterized by loss of nucleus pulposus cells due to excessive apoptosis caused by various factors. MicroRNAs (miRNAs) have been reported to be functionally involved in the control of apoptosis.

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