Lentivirus-TAZ Administration Alleviates Osteoporotic Phenotypes in the Femoral Neck of Ovariectomized Rats | Zendy

Zhanhai Yin | Zendy; Yan Zhang | Zendy; Zheyang Wang | Zendy; Lin Ding | Zendy; Ainiwaerjiang Damaolar | Zendy; Zhiqiang Li | Zendy; Yusheng Qiu | Zendy

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Lentivirus-TAZ Administration Alleviates Osteoporotic Phenotypes in the Femoral Neck of Ovariectomized Rats

Author(s) -

Zhanhai Yin,

Yan Zhang,

Zheyang Wang,

Lin Ding,

Ainiwaerjiang Damaolar,

Zhiqiang Li,

Yusheng Qiu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438629

Subject(s) - ovariectomized rat , osteoporosis , osteocalcin , endocrinology , femoral neck , medicine , bone mineral , runx2 , chemistry , osteoblast , estrogen , alkaline phosphatase , biochemistry , in vitro , enzyme

Osteoporosis is characterized by impairment of bone mass, strength, and microarchitecture, leading to the susceptibility to fragility fractures, especially in femoral neck region. Transcriptional coactivator with PDZ-binding motif (TAZ) facilitates osteogenesis while suppressing adipogenesis via regulation of transcriptional activities of runt-related transcription factor 2 and peroxisome proliferator-activated receptor x03B3;. Here, we validated the role of TAZ in vivo using an ovariectomized (OVX) rat model of osteoporosis.

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