Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy | Zendy

Zhou Zi-chao | Zendy; Zhijian You | Zendy

Open Access

Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy

Author(s) -

Zhou Zi-chao,

Zhijian You

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438627

Subject(s) - mesenchymal stem cell , downregulation and upregulation , autophagy , western blot , flow cytometry , transplantation , microrna , lung , medicine , cd31 , immunology , cancer research , biology , pathology , apoptosis , immunohistochemistry , biochemistry , gene

Damages of pulmonary endothelial cells (PECs) represent a critical pathological process during acute lung injury (ALI), and precede pulmonary epithelial cell injury, and long-term lung dysfunction. Transplantation of mesenchymal stem cells (MSCs) has proven therapeutic effects on ALI, whereas the underlying mechanisms remain ill-defined.

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