Connexin 43 Affects Osteogenic Differentiation of the Posterior Longitudinal Ligament Cells via Regulation of ERK Activity by Stabilizing Runx2 in Ossification | Zendy

Haisong Yang | Zendy; Lei Shi | Zendy; Guodong Shi | Zendy; Yongfei Guo | Zendy; Dechun Chen | Zendy; Deyu Chen | Zendy; Jiangang Shi | Zendy

Open Access

Connexin 43 Affects Osteogenic Differentiation of the Posterior Longitudinal Ligament Cells via Regulation of ERK Activity by Stabilizing Runx2 in Ossification

Author(s) -

Haisong Yang,

Lei Shi,

Guodong Shi,

Yongfei Guo,

Dechun Chen,

Deyu Chen,

Jiangang Shi

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438625

Subject(s) - runx2 , connexin , mapk/erk pathway , osteoblast , osteocalcin , microbiology and biotechnology , gene silencing , chemistry , biology , kinase , gap junction , in vitro , intracellular , alkaline phosphatase , biochemistry , gene , enzyme

Connexin 43 is one of the most potent gap junction proteins related to osteoblast differentiation and bone formation. We hypothesized that Connexin 43 is a significant factor in osteogenic differentiation in the posterior longitudinal ligament through the regulation of extracellular signal-regulated kinases (ERK) activity by converging on Runt-related transcription factor 2 (Runx2) activity. In this study, we mapped the activity of Connexin 43 to ERK and Runx2 by extracting longitudinal ligament cell for culture and silencing Connexin expression in addition to dexamethasone treatment in vitro.

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