PU.1-Silenced Dendritic Cells Induce Mixed Chimerism and Alleviate Intestinal Transplant Rejection in Rats via a Th1 to Th2 Shift | Zendy

Xingwei Xu | Zendy; Xin Gao | Zendy; XiaoFan Zhao | Zendy; Yannian Liao | Zendy; Ji Wu | Zendy; Qiurong Li | Zendy; Jieshou Li | Zendy

Open Access

PU.1-Silenced Dendritic Cells Induce Mixed Chimerism and Alleviate Intestinal Transplant Rejection in Rats via a Th1 to Th2 Shift

Author(s) -

Xingwei Xu,

Xin Gao,

XiaoFan Zhao,

Yannian Liao,

Ji Wu,

Qiurong Li,

Jieshou Li

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438623

Subject(s) - immunosuppression , medicine , transplantation , immunology , immune tolerance , immune system , bone marrow , transplantation chimera , haematopoiesis , biology , stem cell , hematopoietic cell , genetics

Intestinal transplantation is an effective treatment for end-stage bowel failure; however, graft rejection and the toxicity associated with non-specific immunosuppression are major limitations of this procedure. Studies have shown that mixed chimerism can produce post-transplantation immune tolerance. Here, we demonstrate that in rat intestinal transplantation, PU.1-silenced dendritic cells (DCs) plus bone marrow (BM) cell transfusion results in mixed chimerism, and we investigate the mechanisms responsible for the effects of mixed chimerism rejection.

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