Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway | Zendy

Jiangyou Wang | Zendy; Han Chen | Zendy; You Zhou | Zendy; Qiang Su | Zendy; Tao Liu | Zendy; Xiantao Wang | Zendy; Lang Li | Zendy

Open Access

Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway

Author(s) -

Jiangyou Wang,

Han Chen,

You Zhou,

Qiang Su,

Tao Liu,

Xiantao Wang,

Lang Li

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438622

Subject(s) - pten , tensin , atorvastatin , pi3k/akt/mtor pathway , protein kinase b , apoptosis , tunel assay , phosphatase , cancer research , medicine , phosphorylation , chemistry , biology , microbiology and biotechnology , biochemistry

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) has been recognized as a promoter of apoptosis in various tissues, and revealed to be up-regulated in circumstances of coronary microembolization (CME). However, whether this functional protein could be modified by pretreatment of atorvastatin in models of CME has not been disclosed yet.

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