Hydrogen Sulfide Attenuates Myocardial Hypoxia-Reoxygenation Injury by Inhibiting Autophagy via mTOR Activation | Zendy

Jian Xiao | Zendy; Xiaoyan Zhu | Zendy; Bo Kang | Zendy; Jibin Xu | Zendy; Lihui Wu | Zendy; Hong Jiang | Zendy; Yufeng Zhang | Zendy; Xin Ni | Zendy; Zhig Wang | Zendy

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Hydrogen Sulfide Attenuates Myocardial Hypoxia-Reoxygenation Injury by Inhibiting Autophagy via mTOR Activation

Author(s) -

Jian Xiao,

Xiaoyan Zhu,

Bo Kang,

Jibin Xu,

Lihui Wu,

Hong Jiang,

Yufeng Zhang,

Xin Ni,

Zhig Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438597

Subject(s) - autophagy , pi3k/akt/mtor pathway , lactate dehydrogenase , hypoxia (environmental) , chemistry , apoptosis , pharmacology , medicine , biochemistry , enzyme , organic chemistry , oxygen

Autophagy plays a significant role in myocardial ischemia reperfusion (IR) injury. Hydrogen sulfide (H2S) has been demonstrated to protect cardiomyocytes against IR injury, while whether it has anti-autophagy effect has not been known. The aim of this study was to investigate whether H2S regulates autophagy during IR injury and its possible mechanism.

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