TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells | Zendy

Biyong Deng | Zendy; Youwei Feng | Zendy; Bixiang Deng | Zendy

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TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells

Author(s) -

Biyong Deng,

Youwei Feng,

Bixiang Deng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438596

Subject(s) - osteosarcoma , small hairpin rna , medicine , cancer research , cell culture , transfection , cell , western blot , tumor necrosis factor alpha , matrix metalloproteinase , chemistry , biology , gene knockdown , biochemistry , gene , genetics

Osteosarcoma (OS) is a primary malignant bone tumor in humans, and is notorious mainly for its distal metastases. We have recently shown that Shikonin, an effective constituent extracted from Chinese medicinal herb, inhibits OS cell invasion through suppression of matrix metalloproteinase 13 (MMP13). However, the underlying mechanisms remain unknown.

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