Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation | Zendy

Xiao-Mei Teng | Zendy; Lei Chen | Zendy; Weiqian Chen | Zendy; Junjie Yang | Zendy; Ziying Yang | Zendy; Zhenya Shen | Zendy

Open Access

Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

Author(s) -

Xiao-Mei Teng,

Lei Chen,

Weiqian Chen,

Junjie Yang,

Ziying Yang,

Zhenya Shen

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438594

Subject(s) - mesenchymal stem cell , microvesicles , angiogenesis , medicine , exosome , inflammation , neovascularization , myocardial infarction , immunology , cancer research , pathology , biology , microrna , biochemistry , gene

Bone marrow mesenchymal stem cells (MSCs) widely applied for treating myocardial infarction face survival challenges in the inflammatory and ischemia microenvironment of acute myocardial infarction. The study hypothesized that MSC-derived exosomes play a significant role in improving microenvironment after acute myocardial infarction and aimed to investigate the paracrine effects of exosomes on angiogenesis and anti-inflammatory activity.

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