Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer | Zendy

Wen Gao | Zendy; Jing Xu | Zendy; Fuqiang Wang | Zendy; Long Zhang | Zendy; Rui Peng | Zendy; Yunxia Zhu | Zendy; Qiyun Tang | Zendy; Jindao Wu | Zendy

Open Access

Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer

Author(s) -

Wen Gao,

Jing Xu,

Fuqiang Wang,

Long Zhang,

Rui Peng,

Yunxia Zhu,

Qiyun Tang,

Jindao Wu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438588

Subject(s) - vdac1 , proteomics , hsp60 , cancer , biology , carcinogenesis , heat shock protein , proteome , mitochondrion , sod2 , voltage dependent anion channel , quantitative proteomics , cancer research , microbiology and biotechnology , biochemistry , oxidative stress , hsp70 , superoxide dismutase , bacterial outer membrane , genetics , gene , escherichia coli

Gastric cancer (GC) remains the second leading cause of cancer-related deaths in the world. Successful early cancer detection is hampered by lack of highly sensitive and specific biomarkers. Mitochondrial dysfunction contributes to an aggressive carcinogenic phenotype of many cancers. We hypothesized that changes in the mitochondrial proteome are required to support development of GC.

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