Melatonin Induces Cell Apoptosis in AGS Cells Through the Activation of JNK and P38 MAPK and the Suppression of Nuclear Factor-Kappa B: a Novel Therapeutic Implication for Gastric Cancer | Zendy

Weimin Li | Zendy; Mengdi Fan | Zendy; Yina Chen | Zendy; Qian Zhao | Zendy; Caiyun Song | Zendy; Ye Yan | Zendy; Yin Jin | Zendy; Zhiming Huang | Zendy; Chunjing Lin | Zendy; Jian Wu | Zendy

Open Access

Melatonin Induces Cell Apoptosis in AGS Cells Through the Activation of JNK and P38 MAPK and the Suppression of Nuclear Factor-Kappa B: a Novel Therapeutic Implication for Gastric Cancer

Author(s) -

Weimin Li,

Mengdi Fan,

Yina Chen,

Qian Zhao,

Caiyun Song,

Ye Yan,

Yin Jin,

Zhiming Huang,

Chunjing Lin,

Jian Wu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438587

Subject(s) - apoptosis , melatonin , mapk/erk pathway , p38 mitogen activated protein kinases , cancer research , cancer , nfkb1 , cancer cell , medicine , immunology , biology , microbiology and biotechnology , signal transduction , transcription factor , biochemistry , gene

Melatonin, synthesized by the pineal gland and released into the blood, appears to have antitumour properties; however, the mechanisms of its anti-cancer effects are largely unknown, especially in stomach cancer. Here, we explore the antitumour activity of melatonin in a gastric cancer cell line (AGS) and analyse its molecular mechanisms.

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