Open AccessMicroRNA-145 Suppresses Osteosarcoma Metastasis via Targeting MMP16
Author(s) -
Bin Chen,
Zhonglian Huang,
Yuantao Zhang,
Youbin Chen,
Zhanchun Li
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438575
Subject(s) - metastasis , microrna , transfection , osteosarcoma , cancer research , downregulation and upregulation , reporter gene , luciferase , biology , gene expression , chemistry , medicine , cell culture , cancer , gene , genetics
Metastasis is a leading cause of mortality for osteosarcoma (OS) patients, and its molecular pathological mechanisms remain to be elucidated. Previous studies have suggested a significant role of microRNAs (miRNAs) in the control of cancel cell migration and invasion.
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