Role of Hyperketonemia in Inducing Oxidative Stress and Cellular Damage in Cultured Hepatocytes and Type 1 Diabetic Rat Liver | Zendy

Preeti Kanikarla Marie | Zendy; Sushil K. Jain | Zendy

Open Access

Role of Hyperketonemia in Inducing Oxidative Stress and Cellular Damage in Cultured Hepatocytes and Type 1 Diabetic Rat Liver

Author(s) -

Preeti Kanikarla Marie,

Sushil K. Jain

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438573

Subject(s) - oxidative stress , ketone bodies , endocrinology , medicine , gclc , hepatocyte , glutathione , diabetes mellitus , chemistry , biochemistry , metabolism , in vitro , enzyme

Type 1 diabetic (T1D) patients have a higher incidence of liver disease. T1D patients frequently experience elevated plasma ketone levels along with hyperglycemia. However, no study has examined whether hyperketonemia per se has any role in excess liver damage in T1D. This study investigates the hypothesis that hyperketonemia can induce oxidative stress and cellular dysfunction.

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