Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis | Zendy

Shuangshuang Jia | Zendy; Xin Liu | Zendy; Weiyang Li | Zendy; Jieshi Xie | Zendy; Le Yang | Zendy; Liying Li | Zendy

Open Access

Peroxisome Proliferator-Activated Receptor Gamma Negatively Regulates the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Toward Myofibroblasts in Liver Fibrogenesis

Author(s) -

Shuangshuang Jia,

Xin Liu,

Weiyang Li,

Jieshi Xie,

Le Yang,

Liying Li

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438567

Subject(s) - myofibroblast , mesenchymal stem cell , microbiology and biotechnology , chemistry , fibrosis , cellular differentiation , bone marrow , hepatic stellate cell , cancer research , pathology , biology , immunology , endocrinology , medicine , biochemistry , gene

Bone marrow-derived mesenchymal stem cells (BMSCs) have been confirmed to have capacity to differentiate toward hepatic myofibroblasts, which contribute to fibrogenesis in chronic liver diseases. Peroxisome proliferator-activated receptor gamma (PPARx03B3;), a ligand-activated transcription factor, has gained a great deal of recent attention as it is involved in fibrosis and cell differentiation. However, whether it regulates the differentiation of BMSCs toward myofibroblasts remains to be defined.

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