Superoxide Dismutase 1 Regulation of CXCR4-Mediated Signaling in Prostate Cancer Cells is Dependent on Cellular Oxidative State | Zendy

Brent Young | Zendy; Chad Purcell | Zendy; YiQun Kuang | Zendy; Nicholle Charette | Zendy; Denis J. Dupré | Zendy

Open Access

Superoxide Dismutase 1 Regulation of CXCR4-Mediated Signaling in Prostate Cancer Cells is Dependent on Cellular Oxidative State

Author(s) -

Brent Young,

Chad Purcell,

YiQun Kuang,

Nicholle Charette,

Denis J. Dupré

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438566

Subject(s) - sod1 , prostate cancer , cancer cell , superoxide dismutase , metastasis , signal transduction , microbiology and biotechnology , cancer , biology , cancer research , oxidative stress , protein kinase b , cell growth , chemistry , biochemistry , genetics

CXCL12, acting via one of its G protein-coupled receptors, CXCR4, is a chemoattractant for a broad range of cell types, including several types of cancer cells. Elevated expression of CXCR4, and its ligand CXCL12, play important roles in promoting cancer metastasis. Cancer cells have the potential for rapid and unlimited growth in an area that may have restricted blood supply, as oxidative stress is a common feature of solid tumors. Recent studies have reported that enhanced expression of cytosolic superoxide dismutase (SOD1), a critical enzyme responsible for regulation of superoxide radicals, may increase the aggressive and invasive potential of malignant cells in some cancers.

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