SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels | Zendy

Bernat Elvira | Zendy; Jamshed Warsi | Zendy; Myriam Fezai | Zendy; Carlos Muñoz | Zendy; Florian Läng | Zendy

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SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels

Author(s) -

Bernat Elvira,

Jamshed Warsi,

Myriam Fezai,

Carlos Muñoz,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438563

Subject(s) - kinase , chemistry , xenopus , microbiology and biotechnology , protein kinase a , nigericin , biochemistry , biology , membrane , gene

KCNQ1/E1 channels are expressed in diverse tissues and serve a variety of functions including endolymph secretion in the inner ear, cardiac repolarization, epithelial transport and cell volume regulation. Kinases involved in regulation of epithelial transport and cell volume include SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), which are under control of WNK (with-no-K[Lys]) kinases. The present study explored whether KCNQ1/E1 channels are regulated by SPAK and/or OSR1.

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