Enhanced Store-Operated Calcium Entry in Platelets is Associated with Peripheral Artery Disease in Type 2 Diabetes | Zendy

Weijie Xia | Zendy; Yingsha Li | Zendy; Bin Wang | Zendy; Jing Chen | Zendy; Xiaojing Wang | Zendy; Qianqian Sun | Zendy; Fang Sun | Zendy; Zhiyong Li | Zendy; Zhigang Zhao | Zendy

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Enhanced Store-Operated Calcium Entry in Platelets is Associated with Peripheral Artery Disease in Type 2 Diabetes

Author(s) -

Weijie Xia,

Yingsha Li,

Bin Wang,

Jing Chen,

Xiaojing Wang,

Qianqian Sun,

Fang Sun,

Zhiyong Li,

Zhigang Zhao

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438555

Subject(s) - platelet , medicine , endocrinology , calcium , orai1 , platelet activation , diabetes mellitus , stim1 , calcium in biology

Platelet dysfunction plays an important role in thrombosis in diabetes with peripheral artery disease (PAD). Store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) regulate platelet activity by modulating calcium influx. We hypothesized that enhanced SOCE in platelets is associated with diabetes with PAD.

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