Role of Toll-Like Receptor 3 Gene Polymorphisms in Preeclampsia | Zendy

Aiping Chen | Zendy; Congying Li | Zendy; Jingli Wang | Zendy; Han Sha | Zendy; Shun-Fu Piao | Zendy; Shiguo Liu | Zendy

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Role of Toll-Like Receptor 3 Gene Polymorphisms in Preeclampsia

Author(s) -

Aiping Chen,

Congying Li,

Jingli Wang,

Han Sha,

Shun-Fu Piao,

Shiguo Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438553

Subject(s) - preeclampsia , genotype , allele , snp , immunology , toll like receptor , medicine , allele frequency , genotype frequency , polymorphism (computer science) , population , immune system , pregnancy , single nucleotide polymorphism , biology , genetics , gene , innate immune system , environmental health

Accumulating evidence suggests that an excessive maternal systemic inflammatory response to pregnancy with exaggerated activation of the innate immune system plays a critical role in the development of preeclampsia (PE). In this study, we investigated whether polymorphisms in the Toll-like receptor 3 (TLR3) gene are associated with susceptibility to PE in the Chinese Han population.

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