CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin | Zendy

Eun Jung Sohn | Zendy; DeokBeom Jung | Zendy; Jihyun Lee | Zendy; Sang Wook Yoon | Zendy; Gunho Won | Zendy; Hyun Suk Ko | Zendy; SungHoon Kim | Zendy

Open Access

CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin

Author(s) -

Eun Jung Sohn,

DeokBeom Jung,

Jihyun Lee,

Sang Wook Yoon,

Gunho Won,

Hyun Suk Ko,

SungHoon Kim

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438549

Subject(s) - 3t3 l1 , downregulation and upregulation , adipogenesis , adiponectin , adipocyte , gene knockdown , biology , chemistry , endocrinology , lipogenesis , microbiology and biotechnology , medicine , cancer research , cell culture , adipose tissue , biochemistry , insulin resistance , insulin , genetics , gene

Though CCR4-NOT2 (CNOT2), one of CCR4-NOT complex subunits, was known to be involved in metastasis and apoptosis through transcription and mRNA degradation, its other biological function is poorly understood so far. The aim of this study is to elucidate the molecular role of CNOT2 in the differentiation process of 3T3-L1 preadipocytes.

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