SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch | Zendy

Kai Huang | Zendy; Zhi-Qiang Yan | Zendy; Dan Zhao | Zendy; Si-Guo Chen | Zendy; Li-Zhi Gao | Zendy; Ping Zhang | Zendy; BaoRong Shen | Zendy; HaiChao Han | Zendy; Ying-Xin Qi | Zendy; Zong-Lai Jiang | Zendy

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SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch

Author(s) -

Kai Huang,

Zhi-Qiang Yan,

Dan Zhao,

Si-Guo Chen,

Li-Zhi Gao,

Ping Zhang,

BaoRong Shen,

HaiChao Han,

Ying-Xin Qi,

Zong-Lai Jiang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438544

Subject(s) - vascular smooth muscle , calponin , microbiology and biotechnology , activator (genetics) , transfection , sirtuin 1 , chemistry , resveratrol , biology , downregulation and upregulation , endocrinology , medicine , actin , biochemistry , smooth muscle , receptor , gene

Physiological mechanical stretch in vivo helps to maintain the quiescent contractile differentiation of vascular smooth muscle cells (VSMCs), but the underlying mechanisms are still unclear. Here, we investigated the effects of SIRT1 in VSMC differentiation in response to mechanical cyclic stretch.

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