Stimulation of Eryptosis by Narasin | Zendy

Ghada Bouguerra | Zendy; Rosi Bissinger | Zendy; Salem Abbès | Zendy; Florian Läng | Zendy

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Stimulation of Eryptosis by Narasin

Author(s) -

Ghada Bouguerra,

Rosi Bissinger,

Salem Abbès,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438543

Subject(s) - phosphatidylserine , ceramide , chemistry , apoptosis , annexin , sphingomyelin , cytosol , flow cytometry , pharmacology , biophysics , microbiology and biotechnology , phospholipid , biology , biochemistry , membrane , enzyme

Narasin, an ionophore used for the treatment of coccidiosis, has been shown to foster apoptosis of tumor cells. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Eryptosis may be triggered by Ca2+ entry with subsequent increase of cytosolic Ca2+ activity ([Ca2+]i), and by ceramide. The present study explored, whether and how narasin induces eryptosis.

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