Open AccessFree Fatty Acids Impair FGF21 Action in HepG2 Cells
Author(s) -
Mohamed Asrih,
Christophe Montessuit,
Jacques Philippé,
François R. Jornayvaz
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000438540
Subject(s) - fgf21 , lipogenesis , lipid metabolism , endocrinology , medicine , fatty acid synthase , ampk , chemistry , metabolism , fatty acid , biology , biochemistry , fibroblast growth factor , phosphorylation , receptor , protein kinase a
Fibroblast growth factor 21 (FGF21) is a key mediator of glucose and lipid metabolism. However, the beneficial effects of exogenous FGF21 administration are attenuated in obese animals and humans with elevated levels of circulating free fatty acids (FFA).
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