Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide | Zendy

Guilai Liu | Zendy; Guoxing Liu | Zendy; Hong Chen | Zendy; Kousi Alzoubi | Zendy; Anja T. Umbach | Zendy; Meinrad Gawaz | Zendy; Christos Stournaras | Zendy; Florian Läng | Zendy

Open Access

Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide

Author(s) -

Guilai Liu,

Guoxing Liu,

Hong Chen,

Kousi Alzoubi,

Anja T. Umbach,

Meinrad Gawaz,

Christos Stournaras,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438539

Subject(s) - thapsigargin , ionomycin , platelet , platelet activation , orai1 , thrombin , chemistry , microbiology and biotechnology , biophysics , medicine , stim1 , biochemistry , biology , intracellular , membrane

Blood platelets accomplish primary hemostasis following vascular injury and contribute to the orchestration of occlusive vascular disease. Platelets are activated by an increase of cytosolic Ca2+-activity ([Ca2+]i), which is accomplished by Ca2+-release from intracellular stores and subsequent store operated Ca2+ entry (SOCE) through Ca2+ release activated Ca2+ channel moiety Orai1. Powerful activators of platelets include thrombin and collagen related peptide (CRP), which are in part effective by activation of small G- protein Rac1. The present study explored the influence of thrombin and CRP on Orai1 protein abundance and cytosolic Ca2+-activity ([Ca2+]i) in platelets drawn from wild type mice.

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