Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma | Zendy

Wei Huang | Zendy; Junyu Wang | Zendy; Danfeng Zhang | Zendy; Wen Chen | Zendy; Lijun Hou | Zendy; Xiaojun Wu | Zendy; Yicheng Lu | Zendy

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Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma

Author(s) -

Wei Huang,

Junyu Wang,

Danfeng Zhang,

Wen Chen,

Lijun Hou,

Xiaojun Wu,

Yicheng Lu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438532

Subject(s) - apoptosis , glioblastoma , cell growth , cancer research , microbiology and biotechnology , chemistry , biology , biochemistry

The mitotic kinesin superfamily protein KIF14 is essential for cytokinesis and chromosome segregation, and increased KIF14 expression is related to a variety of human cancers. However, the role of KIF14 in the development and malignant progression of astrocytomas and the underlying mechanisms remain unclear. The present study examined the relation between KIF14 and the pathogenesis of malignant astrocytoma.

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