Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway | Zendy

Ruolan Dong | Zendy; Wenshu Chen | Zendy; Wenjing Feng | Zendy; Congying Xia | Zendy; Danli Hu | Zendy; Yanjun Zhang | Zendy; Yan Yang | Zendy; Dao Wen Wang | Zendy; Xizhen Xu | Zendy; Ling Tu | Zendy

Open Access

Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway

Author(s) -

Ruolan Dong,

Wenshu Chen,

Wenjing Feng,

Congying Xia,

Danli Hu,

Yanjun Zhang,

Yan Yang,

Dao Wen Wang,

Xizhen Xu,

Ling Tu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438526

Subject(s) - bradykinin , umbilical vein , protein kinase b , medicine , signal transduction , tissue factor , pi3k/akt/mtor pathway , endocrinology , chemistry , pharmacology , biology , microbiology and biotechnology , receptor , in vitro , biochemistry , coagulation

Bradykinin has been shown to exert a variety of protective effects against vascular injury, and to reduce the levels of several factors involved in the coagulation cascade. A key determinant of thrombin generation is tissue factor (TF). However, whether bradykinin can regulate TF expression remains to be investigated.

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